Śrīvatsa Goswāmī of Rādhā-ramaṇa Mandir told me the same as can be read in this article, be it in less detail, in Vṛndāvan in 1985. Śrīvatsa Goswāmī said that Vaiṣṇavas drew tilak on the picture after cutting it out from this painting - they needed a picture for altar worship. Other drawings, of the 6 Goswāmīs, Viśvanātha Cakravartīpāda etc. are also man-made. The link to Jahangir-nama manuscript under the 4th illustration leads to a Columbia.edu webpage that proves the painting is of the court of Jahangir. Jahangir was born in 1569, some 15 years after Rūpa Goswāmī left this world. That is certain proof that the person depicted there is not Rūpa Goswāmī.